Long-Range Control of Gene Expression: Emerging Mechanisms and Disruption in Disease
Identifieur interne : 008777 ( Main/Exploration ); précédent : 008776; suivant : 008778Long-Range Control of Gene Expression: Emerging Mechanisms and Disruption in Disease
Auteurs : Dirk A. Kleinjan ; Veronica Van HeyningenSource :
- American Journal of Human Genetics [ 0002-9297 ] ; 2004.
Abstract
Transcriptional control is a major mechanism for regulating gene expression. The complex machinery required to effect this control is still emerging from functional and evolutionary analysis of genomic architecture. In addition to the promoter, many other regulatory elements are required for spatiotemporally and quantitatively correct gene expression. Enhancer and repressor elements may reside in introns or up- and downstream of the transcription unit. For some genes with highly complex expression patterns—often those that function as key developmental control genes—the
Url:
PubMed: 15549674
PubMed Central: 1196435
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000037
- to stream Pmc, to step Curation: 000037
- to stream Pmc, to step Checkpoint: 003E35
- to stream Ncbi, to step Merge: 001C11
- to stream Ncbi, to step Curation: 001C11
- to stream Ncbi, to step Checkpoint: 001C11
- to stream Main, to step Merge: 008A34
- to stream Main, to step Curation: 008777
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-Range Control of Gene Expression: Emerging Mechanisms and Disruption in Disease</title>
<author><name sortKey="Kleinjan, Dirk A" sort="Kleinjan, Dirk A" uniqKey="Kleinjan D" first="Dirk A." last="Kleinjan">Dirk A. Kleinjan</name>
</author>
<author><name sortKey="Van Heyningen, Veronica" sort="Van Heyningen, Veronica" uniqKey="Van Heyningen V" first="Veronica" last="Van Heyningen">Veronica Van Heyningen</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">15549674</idno>
<idno type="pmc">1196435</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196435</idno>
<idno type="RBID">PMC:1196435</idno>
<date when="2004">2004</date>
<idno type="wicri:Area/Pmc/Corpus">000037</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000037</idno>
<idno type="wicri:Area/Pmc/Curation">000037</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000037</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003E35</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003E35</idno>
<idno type="wicri:Area/Ncbi/Merge">001C11</idno>
<idno type="wicri:Area/Ncbi/Curation">001C11</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C11</idno>
<idno type="wicri:doubleKey">0002-9297:2004:Kleinjan D:long:range:control</idno>
<idno type="wicri:Area/Main/Merge">008A34</idno>
<idno type="wicri:Area/Main/Curation">008777</idno>
<idno type="wicri:Area/Main/Exploration">008777</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Long-Range Control of Gene Expression: Emerging Mechanisms and Disruption in Disease</title>
<author><name sortKey="Kleinjan, Dirk A" sort="Kleinjan, Dirk A" uniqKey="Kleinjan D" first="Dirk A." last="Kleinjan">Dirk A. Kleinjan</name>
</author>
<author><name sortKey="Van Heyningen, Veronica" sort="Van Heyningen, Veronica" uniqKey="Van Heyningen V" first="Veronica" last="Van Heyningen">Veronica Van Heyningen</name>
</author>
</analytic>
<series><title level="j">American Journal of Human Genetics</title>
<idno type="ISSN">0002-9297</idno>
<idno type="eISSN">1537-6605</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Transcriptional control is a major mechanism for regulating gene expression. The complex machinery required to effect this control is still emerging from functional and evolutionary analysis of genomic architecture. In addition to the promoter, many other regulatory elements are required for spatiotemporally and quantitatively correct gene expression. Enhancer and repressor elements may reside in introns or up- and downstream of the transcription unit. For some genes with highly complex expression patterns—often those that function as key developmental control genes—the <italic>cis</italic>
-regulatory domain can extend long distances outside the transcription unit. Some of the earliest hints of this came from disease-associated chromosomal breaks positioned well outside the relevant gene. With the availability of wide-ranging genome sequence comparisons, strong conservation of many noncoding regions became obvious. Functional studies have shown many of these conserved sites to be transcriptional regulatory elements that sometimes reside inside unrelated neighboring genes. Such sequence-conserved elements generally harbor sites for tissue-specific DNA-binding proteins. Developmentally variable chromatin conformation can control protein access to these sites and can regulate transcription. Disruption of these finely tuned mechanisms can cause disease. Some regulatory element mutations will be associated with phenotypes distinct from any identified for coding-region mutations.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Kleinjan, Dirk A" sort="Kleinjan, Dirk A" uniqKey="Kleinjan D" first="Dirk A." last="Kleinjan">Dirk A. Kleinjan</name>
<name sortKey="Van Heyningen, Veronica" sort="Van Heyningen, Veronica" uniqKey="Van Heyningen V" first="Veronica" last="Van Heyningen">Veronica Van Heyningen</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008777 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008777 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:1196435 |texte= Long-Range Control of Gene Expression: Emerging Mechanisms and Disruption in Disease }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:15549674" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |